A private jet crashed into houses in Philadelphia on Friday night, just two days after a plane-helicopter collision occurred near Washington, D.C. 

Transportation Secretary Sean Duffy said that six people were reportedly aboard the plane that crashed into the homes, which caused an explosion and set multiple homes on fire. The crash occurred around 6:30 p.m.

Jet Rescue Air Ambulance, which operated the jet, said the pilot, a copilot, a physician, a paramedic, the patient, and an escort for the patient were on board the plane. The jet was also equipped with medical equipment. 

A spokesperson for the company told NBC Philadelphia that the patient was a child who had come to the U.S. for "life-saving treatment" and was returning to Mexico.

"The treatment ran its course. She was ready to go home, and we were contracted to bring her back home to Mexico," the spokesperson said. "The ultimate destination was the Tijuana International Airport and was scheduled to go home by ground ambulance." 

Injuries have also been reported on the ground, but it is not clear how many people have been injured. The status of the six individuals on the plane was not immediately known. 

The Federal Aviation Administration said in a statement on X that the jet departed from Northeast Philadelphia Airport and was en route to Springfield-Branson National Airport in Missouri. It was going to refuel there before resuming to Tijuana. 

"The FAA and [National Transportation Safety Board (NTSB)] will investigate," the FAA said. "The NTSB will lead the investigation and will provide all updates."

Police told CBS News that some cars in the area were hit by the plane and some businesses near the Roosevelt Mall are also on fire. 

President Donald Trump confirmed that he has been briefed on the situation.

"So sad to see the plane go down in Philadelphia, Pennsylvania. More innocent souls lost," Trump posted on Truth Social. "Our people are totally engaged. First Responders are already being given credit for doing a great job. More to follow. God Bless you all."

The cause of the crash was not immediately clear. A video of the crash can be viewed here.

Misty Severi is a news reporter for Just The News. You can follow her on X for more coverage.