Shalala out, Lamb behind, Klacik falls short, Issa's return still alive in high-profile House races

House Democrats kept their majority Tuesday night but lost a few high-profilers along the way including Florida Rep. Donna Shalala, while on the Republican side Trump-backed Kimberly Klacik failed to flip a Baltimore-area seat and Darrell Issa waits to learn the outcome of his comeback quest. 

In losing her Miami-area seat, Shalala appeared to fall victim, at least in part, to Democratic presidential candidate Joe Biden's failure to connect with Hispanic and other minority voters in Florida's Miami-Dade area. 

Rep. Debbie Mucarsel-Powell, a Democrat in a nearby district, was also defeated. Shalala, served as President Clinton’s health secretary.

In a rare situation in which a leader of a congressional committee loses reelection, Democrat Rep. Collin Peterson, chairman of the House Agriculture was defeated. The Minnesota lawmaker, in the state's seventh congressional district, has severed in Congress for roughly 30 years. 

In 2018, Democrat Conor Lamb won a special House election in a Republican-stronghold outside of Pittsburgh, marking what his party considered a voter rebuke of President Trump's win in Pennsylvania two years earlier.

However Lamb, for whom Democratic presidential candidate Joe Biden has campaigned, as of early Wednesday was trailing in his reelection bid. 

Klacik, a black female candidate, couldn't unseat Democrat Kweisi Mfume, despite a viral video shot amid Baltimore's acres of abandoned and boarded-up homes, which caught President Trump's attention and brought million of outside money to her campaign.

Issa, a former California GOP congressman, remained neck-and-neck Wednesday morning in his comeback bid.

Issa, also a former chairman of the House Oversight committee, retired from Congress in 2018 ahead of the blue tsunami in Southern California. He is attempting to return to Capitol Hill by running for the nearby House seat formally occupied by disgraced GOP Rep. Duncan Hunter.